| LCN2 |
| LOCUS ID | 3934 | |||||||||||||
| GENE_SYMBOL | LCN2 | |||||||||||||
| GENE NAME | lipocalin 2 | |||||||||||||
| SYNONYMNS | p25, 24p3, MSFI,NGAL | |||||||||||||
| CHROMOSOME | 9 | |||||||||||||
| HOMOLOGENE ID | 4064 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1.This study identified that higher PIP, THBS2 and/or NGAL levels were significantly associated with nephropathy of T2DM, and higher L1CAM but normal PIP, THBS2 or NGAL was significantly associated with retinopathy of T2DM. | 27446820 |
| Insulin resistance and inflammation | 1. Reducing LCN2 gene expression causes decreased expression of PPARgamma and adiponectin, slightly reducing insulin-stimulated Akt2 phosphorylation at Serine 473 in 3T3-L1 adipocytes. | 18292240 |