| LEPR |
| LOCUS ID | 3953 | ||||||||||
| GENE_SYMBOL | LEPR | ||||||||||
| GENE NAME | leptin receptor | ||||||||||
| SYNONYMNS | OBR,OB-R,CD295,LEP-R,LEPRD | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 1731 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alter |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. Using network analysis, we have identified several cellular network proteins like PTPN1, AKT1, INSR, LEPR, IRS1, IRS2, IL1R2, IL6R, PCSK9 and MYD88, which are responsible for regulating inflammation, insulin resistance, and atherosclerosis. We have identified three distinct sets of serum markers for diabetes, CAD and diabetes associated with CAD in Indian patients using nonparametric-based machine learning approach. These multiple marker classifiers may be useful for monitoring progression from a healthy person to T2DM and T2DM to T2DM_CAD. | 30674322 |