| LGALS3 |
| LOCUS ID | 3958 | ||||||||||
| GENE_SYMBOL | LGALS3 | ||||||||||
| GENE NAME | galectin 3 | ||||||||||
| SYNONYMNS | L31 GAL3 MAC2 CBP35 GALBP GALIG LGALS2 | ||||||||||
| CHROMOSOME | 14 | ||||||||||
| HOMOLOGENE ID | 37608 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Endothelial transcripts upregulated by HFD included galectin-3 (Lgals3), 5-lipoxygenase-activating protein, and chemokine ligands 8 and 9. | 21791638 |