| LILRB4 |
| LOCUS ID | 11006 | ||||||||||
| GENE_SYMBOL | LILRB4 | ||||||||||
| GENE NAME | leukocyte immunoglob | ||||||||||
| SYNONYMNS | ILT3 LIR5 CD85K ILT-3 LIR-5 | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 86756 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells a |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. The hepatocyte-specific knockout of LILRB4 (LILRB4-HKO) exacerbated high-fat diet-induced insulin resistance, glucose metabolic imbalance, hepatic lipid accumulation, and systematic inflammation in mice, whereas LILRB4 overexpression in hepatocytes showed a completely opposite phenotype relative to that of LILRB4-HKO mice when compared with their corresponding controls. | 29091299 |