| LIMK2 |
| LOCUS ID | 3985 | ||||||||||
| GENE_SYMBOL | LIMK2 | ||||||||||
| GENE NAME | LIM domain kinase 2 | ||||||||||
| SYNONYMNS | NA | ||||||||||
| CHROMOSOME | 22 | ||||||||||
| HOMOLOGENE ID | 55911 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| There are approximately 40 known eukaryotic LIM proteins, so med for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to D or R, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a uniquecombination of 2 N-termil LIM motifs and a C-termil protein kinase domain. The protein encoded by this gene is phosphoryla |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. A combined analysis of all 2890 patients with ESRD showed significant association SNPs in LIMK2 and SFI1 suggesting that they also contribute to all-cause ESRD. Thus, our results suggest that multiple loci underlie susceptibility to kidney disease in African Americans with type 2 diabetes and some may also contribute to all-cause ESRD. | 21150874 |