| LIPE |
| LOCUS ID | 3991 | ||||||||||
| GENE_SYMBOL | LIPE | ||||||||||
| GENE NAME | lipase E, hormone se | ||||||||||
| SYNONYMNS | HSL LHS REH AOMS4 FPLD6 | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 3912 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We found that systemic HSL deficient mice developed fatty liver in an age-dependent fashion between 3 and 8 months of age. | 29232702 |