| LOX |
| LOCUS ID | 4015 | ||||||||||
| GENE_SYMBOL | LOX | ||||||||||
| GENE NAME | lysyl oxidase | ||||||||||
| SYNONYMNS | AAT10 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 1741 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with p |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Inhibition of LOX activity by beta-aminoproprionitrile treatment results in a significant improvement in several metabolic parameters and further reduces local adipose tissue inflammation. | 19546236 |