| LPA |
| LOCUS ID | 4018 | |||||||||||||
| GENE_SYMBOL | LPA | |||||||||||||
| GENE NAME | lipoprotein, Lp(a) | |||||||||||||
| SYNONYMNS | LP, AK38, APOA | |||||||||||||
| CHROMOSOME | 6 | |||||||||||||
| HOMOLOGENE ID | 87856 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represe |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Our data suggest that Lp(a) levels and apo(a) polymorphism may be reliable predictors of Corory artery disease (CAD) severity in type 2 diabetic patients. | 15961173 |
| Atherosclerosis | 1. Considering the importance of LP A-I in preventing atherosclerosis it should be stressed that a decrease in its level during the period of prolonged hypoglycemia constitutes still another risk factor for development of atherosclerosis in diabetic children and adolescents. " | 1345532 |