| Complication | Evidence | PMID |
| Nephropathy | 1. The LPL mass was inversely associated with Von Willebrand factor (vWF), suggesting that widespread endothelial cell damage in a reduction in LPL bound to endothelium in diabetic subjects with microalbuminuria.plasma lipoprotein profiles become more atherogenic in patients with diabetic nephropathy, including the subclinical stage, compared with diabetics without nephropathy or those with nondiabetic kidney disease. | 10412730 |
| Cardiovascular | 1. Polymorphisms in LPL, CETP, and HL Protect HIV-Infected Patients from Atherogenic Dyslipidemia in an Allele-Dose-Dependent Manner. | 26101956 |
| Atherosclerosis | 1. Dysregulation of macrophage PPARs in the arterial wall may contribute, by increasing the in vivo macrophage production of LPL and of proinflammatory cytokines, to the accelerated atherosclerosis associated with diabetes. | 10634806 |
| Neuropathy | 1. These show that streptozotocin (STZ) -induced diabetes causes a decrease in LPL activity in the sciatic nerve that, as in other tissues, is reversible with insulin treatment. These data may suggest a role for LPL in the pathophysiology of diabetic neuropathy. | 11897675 |
| Dyslipidemia | 1. Therefore, LPL may represent a link between low adiponectin and dyslipidemia found in metabolic syndrome and type 2 diabetes mellitus. | 11897675 |
| Insulin resistance and inflammation | 1. Overweight/obese women presented lower LPL activity (P=0.022) and higher circulating TNF-? (P=0.020) than controls. | 24905278 |
