LRP1
LOCUS ID4035
GENE_SYMBOLLRP1
GENE NAMELDL receptor related
SYNONYMNSAPR, KPA, LRP, A2MR, CD91, APOER, LRP1A, TGFBR5, IGFBP3R, IGFBP-3R, IGFBP3R1
CHROMOSOME12
HOMOLOGENE ID1744
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid pr

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. LRP1 and CHOP might be involved in DPN pathogenesis and progression, thus providing opportunities for early detection and treatment.30902789
Insulin resistance and inflammation1. Previously it was shown that Hepatic LRP1 deficiency exacerbates palmitate-induced steatosis and toxicity in vitro and also promotes high-fat diet-induced hepatic insulin resistance and hepatic steatosis in vivo.29752404