| LRP1 |
| LOCUS ID | 4035 | |||||||||||||
| GENE_SYMBOL | LRP1 | |||||||||||||
| GENE NAME | LDL receptor related | |||||||||||||
| SYNONYMNS | APR, KPA, LRP, A2MR, CD91, APOER, LRP1A, TGFBR5, IGFBP3R, IGFBP-3R, IGFBP3R1 | |||||||||||||
| CHROMOSOME | 12 | |||||||||||||
| HOMOLOGENE ID | 1744 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid pr |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. LRP1 and CHOP might be involved in DPN pathogenesis and progression, thus providing opportunities for early detection and treatment. | 30902789 |
| Insulin resistance and inflammation | 1. Previously it was shown that Hepatic LRP1 deficiency exacerbates palmitate-induced steatosis and toxicity in vitro and also promotes high-fat diet-induced hepatic insulin resistance and hepatic steatosis in vivo. | 29752404 |