LRP2
LOCUS ID4036
GENE_SYMBOLLRP2
GENE NAMELDL receptor related
SYNONYMNSDBS,GP330
CHROMOSOME2
HOMOLOGENE ID20952
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E,

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. genetic association exists between a cubilin and a rare megalin variant with diabetes-associated ESRD in populations with recent African ancestry27197912