| LRP2 |
| LOCUS ID | 4036 | ||||||||||
| GENE_SYMBOL | LRP2 | ||||||||||
| GENE NAME | LDL receptor related | ||||||||||
| SYNONYMNS | DBS,GP330 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 20952 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. genetic association exists between a cubilin and a rare megalin variant with diabetes-associated ESRD in populations with recent African ancestry | 27197912 |