| LRPPRC |
| LOCUS ID | 10128 | ||||||||||
| GENE_SYMBOL | LRPPRC | ||||||||||
| GENE NAME | leucine rich pentatr | ||||||||||
| SYNONYMNS | LSFC GP130 LRP130 MC4DN5 CLONE-23970 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 32695 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh sy |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We have ectopically expressed LRPPRC in mouse liver in the setting of NAFLD. Interestingly, ectopic expression of LRPPRC in mouse liver completely interdicted NAFLD, including inflammation. | 25933096 |