| LTA |
| LOCUS ID | 4049 | ||||||||||
| GENE_SYMBOL | LTA | ||||||||||
| GENE NAME | lymphotoxin alpha | ||||||||||
| SYNONYMNS | LT, TNFB, TNFSF1 | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 497 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are assoc |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1.The association between diabetic complications and LTA, TNF and AGER polymorphisms is complex, with partly different alleles conferring susceptibility in type 1 and type 2 diabetic patients. We can not exclude the possibility that the genes are part of a large haplotype block that also includes HLA-DQB1 risk genotypes. | 0 |