MAFB
LOCUS ID9935
GENE_SYMBOLMAFB
GENE NAMEv-maf avian musculoa
SYNONYMNSKRML, MCTO
CHROMOSOME20
HOMOLOGENE ID31315
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. The rs2902940A allele carriers in the MAFB conferred a decreased serum ApoAI level in controls and an increased risk of CAD and IS. The rs2902940GA/AA genotypes interacted with higher BMI, hypertension and diabetes to contribute the risk of CAD and IS26204962
Atherosclerosis1. The rs2902940A allele carriers in the MAFB conferred a decreased serum ApoAI level in controls and an increased risk of CAD and IS.26204962
Insulin resistance and inflammation1. MAFB downregulation decreases proinflammatory gene expression in adipocytes and interferes with TNF-? effects. 26115698