| MALT1 |
| LOCUS ID | 10892 | ||||||||||
| GENE_SYMBOL | MALT1 | ||||||||||
| GENE NAME | MALT1 paracaspase | ||||||||||
| SYNONYMNS | MLT, MLT1, IMD12, PCASP1 | ||||||||||
| CHROMOSOME | 18 | ||||||||||
| HOMOLOGENE ID | 4938 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two altertively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Here we investigated the association of POL1-nearby variant rs488846, MALT1-nearby variant rs2874116, MC4R-nearby variant rs1942872, PHLPP rs9958800 and DSEL-nearby variant rs9966483 single nucleotide polymorphisms (SNPs) in the 18q region, previously linked with DN in African-Americans, with T2DM in (North African) Tunisian subjects, followed by their association with DN, which was performed subsequent to the analysis of the association with T2DM. | 23727064 |