| MAP3K3 |
| LOCUS ID | 4215 | ||||||||||
| GENE_SYMBOL | MAP3K3 | ||||||||||
| GENE NAME | mitogen-activated pr | ||||||||||
| SYNONYMNS | MEKK3 MAPKKK3 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 69110 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it d |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Furthermore, we demonstrate that an interaction between the PB1 domains of NBR1 and the mitogen-activated kinase kinase 3 (MEKK3) enables the formation of a signaling complex required for the activation of JNK. | 25043814 |