| MAP3K5 |
| LOCUS ID | 4217 | |||||||||||||
| GENE_SYMBOL | MAP3K5 | |||||||||||||
| GENE NAME | mitogen-activated pr | |||||||||||||
| SYNONYMNS | ASK1, MEKK5, MAPKKK5 | |||||||||||||
| CHROMOSOME | 6 | |||||||||||||
| HOMOLOGENE ID | 38114 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. In , this study identifies ASK1 as a new therapeutic target in diabetic nephropathy to reduce renal inflammation and fibrosis independent of blood pressure control. | 26180085 |
| Cardiovascular | 1. Apoptosis signal-regulating kinase 1 (ASK1) activates the proapoptotic c-Jun NH2-terminal kinase 1/2 (JNK1/2) leading to apoptosis, suggesting a possible role of ASK1 in diabetes-induced heart defects. | 26173459 |