| MAP3K7 |
| LOCUS ID | 6885 | ||||||||||
| GENE_SYMBOL | MAP3K7 | ||||||||||
| GENE NAME | mitogen-activated pr | ||||||||||
| SYNONYMNS | CSCF FMD2 TAK1 MEKK7 TGF1a | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 135715 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JN |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Mechanistically, we revealed that TGF-?-activated kinase 1 (TAK1/MAP3K7) and its adaptor protein TAK1 binding protein 1 (TAB1) played a dominant role in the regulatory effects of PGC-1? . | 26748475 |