| MAP3K8 |
| LOCUS ID | 1326 | ||||||||||
| GENE_SYMBOL | MAP3K8 | ||||||||||
| GENE NAME | mitogen-activated pr | ||||||||||
| SYNONYMNS | COT EST ESTF TPL2 AURA2 MEKK8 Tpl-2 c-COT | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 3812 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus p |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Individuals with a BMI >30 displayed a higher mRNA expression of MAP3K8 in adipose tissue compared to individuals with a normal BMI. | 24586913 |