| MAP4K4 |
| LOCUS ID | 9448 | ||||||||||
| GENE_SYMBOL | MAP4K4 | ||||||||||
| GENE NAME | mitogen-activated pr | ||||||||||
| SYNONYMNS | HGK NIK MEKKK4 FLH21957 HEL-S-31 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 7442 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different is |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. HGK deficiency induces TRAF2/IL-6 upregulation, leading to IL-6/leptin-induced Th17 differentiation in adipose tissue and subsequent insulin resistance. | 25098764 |