| MAPK1 |
| LOCUS ID | 5594 | |||||||||||||
| GENE_SYMBOL | MAPK1 | |||||||||||||
| GENE NAME | mitogen-activated pr | |||||||||||||
| SYNONYMNS | ERK, p38, p40, p41, ERK2, ERT1, ERK-2, MAPK2, PRKM1, PRKM2, | |||||||||||||
| CHROMOSOME | 22 | |||||||||||||
| HOMOLOGENE ID | 37670 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it p |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. This activated p38 MAPK pathway in diabetic glomeruli may, in part, play a role in the pathogenesis of early hypertrophy and extracellular matrix accumulation. | 11473637 |
| Neuropathy | 1. Increased p38 mitogen-activated protein kinase (MAPK) in response to stress stimuli, including hyperglycemia, contributes to diabetic somatic neuropathy. | 16355109 |