| MAPK14 |
| LOCUS ID | 1432 | ||||||||||
| GENE_SYMBOL | MAPK14 | ||||||||||
| GENE NAME | mitogen-activated pr | ||||||||||
| SYNONYMNS | RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRK | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 31777 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical sigls, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interactio |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Glomerular p38 MAPK activity was increased in early DN. This activated p38 MAPK pathway in diabetic glomeruli may, in part, play a role in the pathogenesis of early hypertrophy and extracellular matrix accumulation. | 11473637 |