| MAPK7 |
| LOCUS ID | 5598 | |||||||||||||
| GENE_SYMBOL | MAPK7 | |||||||||||||
| GENE NAME | mitogen-activated pr | |||||||||||||
| SYNONYMNS | BMK1, ERK4, ERK5, PRKM7 | |||||||||||||
| CHROMOSOME | 17 | |||||||||||||
| HOMOLOGENE ID | 2060 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical sigls, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy. Hence, ERK5 may be a putative therapeutic target to modulate VEGF expression in diabetic retinopathy 2. Our experiments demonstrated a novel mechanism of glucose-induced increased FN production in diabetic retinopathy, which is mediated through decreased ERK5 sigling. 3. ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy. Hence, ERK5 may be a putative therapeutic target to modulate VEGF expression in diabetic retinopathy | 20671964 |
| Insulin resistance and inflammation | 1. We propose a new mechanism by which CO and HO-1 mediate anti-inflammatory effects via activating ERK5/PPARdelta, and ERK5 mediates CO and HO-1-induced PPARdelta activation via its interaction with PPARdelta. | 16943204 |