| MARCO |
| LOCUS ID | 8685 | ||||||||||
| GENE_SYMBOL | MARCO | ||||||||||
| GENE NAME | macrophage receptor | ||||||||||
| SYNONYMNS | SR-A6, SCARA2 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 4928 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of t |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Tuberculosis | 1. Reduced MARCO and CD14 expression contributes to defective sentinel function of alveolar macrophages, promoting tuberculosis susceptibility in diabetic hosts at a critical early step in the immune response to aerosol infection | 27630197 |