MCU
LOCUS ID90550
GENE_SYMBOLMCU
GENE NAMEmitochondrial calciu
SYNONYMNSHsMCU C10orf42 CCDC109A
CHROMOSOME10
HOMOLOGENE ID9916
microRNAsNANA
GENE SUMMARY
This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. Inhibition of MCU by lentiviral-mediated shRNA prevented mitochondrial calcium uptake and downregulated the inflammatory (TNF-?, IL-6) and coagulative (PAI-1 and FGA) mRNA expression in HepG2 cells exposed to HG.29709004