| MCU |
| LOCUS ID | 90550 | ||||||||||
| GENE_SYMBOL | MCU | ||||||||||
| GENE NAME | mitochondrial calciu | ||||||||||
| SYNONYMNS | HsMCU C10orf42 CCDC109A | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 9916 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Inhibition of MCU by lentiviral-mediated shRNA prevented mitochondrial calcium uptake and downregulated the inflammatory (TNF-?, IL-6) and coagulative (PAI-1 and FGA) mRNA expression in HepG2 cells exposed to HG. | 29709004 |