| MEP1B |
| LOCUS ID | 4225 | ||||||||||
| GENE_SYMBOL | MEP1B | ||||||||||
| GENE NAME | meprin A, beta | ||||||||||
| SYNONYMNS | NA | ||||||||||
| CHROMOSOME | 18 | ||||||||||
| HOMOLOGENE ID | 48382 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestil brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestil inflammation. Mature meprins are oligomers of evolutiorily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing t |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The present study demonstrates significant within-family association for SNPs in MEP1B gene with diabetic nephropathy. These could be explained by functional effects of one or more of these SNPs or by linkage disequilibrium with a nearby functional locus. | 15604066 |