| MERTK |
| LOCUS ID | 10461 | ||||||||||
| GENE_SYMBOL | MERTK | ||||||||||
| GENE NAME | MER proto-oncogene, | ||||||||||
| SYNONYMNS | MER RP38 c-Eyk c-mer Tyro12 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 4626 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In the cross-sectional cohort, MERTK A-allele carriers had higher fat oxidation rates and tissue insulin sensitivity. | 28334911 |