MLKL
LOCUS ID197259
GENE_SYMBOLMLKL
GENE NAMEmixed lineage kinase
SYNONYMNShMLKL
CHROMOSOME16
HOMOLOGENE ID77416
microRNAsNANA
GENE SUMMARY
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. Inhibition of MLKL or other key necroptotic regulators enhanced hepatic insulin sensitivity.30837196