| MLKL |
| LOCUS ID | 197259 | ||||||||||
| GENE_SYMBOL | MLKL | ||||||||||
| GENE NAME | mixed lineage kinase | ||||||||||
| SYNONYMNS | hMLKL | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 77416 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Inhibition of MLKL or other key necroptotic regulators enhanced hepatic insulin sensitivity. | 30837196 |