| MME |
| LOCUS ID | 4311 | |||||||||||||
| GENE_SYMBOL | MME | |||||||||||||
| GENE NAME | membrane metallo-end | |||||||||||||
| SYNONYMNS | NEP, SFE, CD10, CALLA | |||||||||||||
| CHROMOSOME | 3 | |||||||||||||
| HOMOLOGENE ID | 5275 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glome |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. These studies suggest that NEP plays a role in regulating nerve function in insulin-deficient diabetes and DIO. | 20849865 |
| Insulin resistance and inflammation | 1. Thus, knockdown of MME in subcutaneous preadipocytes increased the inflammatory response to substance P and amyloid ? aggregates. This associated with increased basal insulin signaling and decreased insulin-stimulated signaling. Moreover, MME differentially regulates the internalization and turnover of the ?/? subunits of the insulin receptor. | 30795914 |