| MMP12 |
| LOCUS ID | 4321 | ||||||||||
| GENE_SYMBOL | MMP12 | ||||||||||
| GENE NAME | matrix metallopeptid | ||||||||||
| SYNONYMNS | ME HME MME MMP-12 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 20547 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In humans, MMP12 expression correlated positively and significantly with insulin resistance, TNF-? expression, and the number of CD14(+)CD206(+) macrophages in adipose tissue. MMP12 was the most abundant matrix metallopeptidase detected by proteomic analysis of conditioned medium of M2 macrophages and dendritic cells. | 24914938 |