| MMP14 |
| LOCUS ID | 4323 | ||||||||||
| GENE_SYMBOL | MMP14 | ||||||||||
| GENE NAME | matrix metallopeptid | ||||||||||
| SYNONYMNS | MMP-14, MMP-X1, MT-MMP, MT1MMP, MTMMP1, WNCHRS, MT1-MMP, | ||||||||||
| CHROMOSOME | 14 | ||||||||||
| HOMOLOGENE ID | 21040 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Proteins of the matrix metalloproteise (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as ictive proproteins which are activated when cleaved by extracellular proteises. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member o |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. These suggest that MMP-2 and MT1-MMP are produced and activated in glomeruli through the progression of diabetic nephropathy and may have some effect on the remodeling of the glomerular matrix in diabetic nephropathy. | 21414971 |