| MMP24 |
| LOCUS ID | 9518 | ||||||||||
| GENE_SYMBOL | MMP24 | ||||||||||
| GENE NAME | Matrix Metallopeptid | ||||||||||
| SYNONYMNS | MMP25, MMP-24, MT5MMP, MTMMP5, MT-MMP5, MT5-MMP, MT-MMP 5 | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 21331 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the peptidase M10 family of matrix metalloproteises (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the mem |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Because renal tubular atrophy is a significant factor in the pathogenesis of diabetic nephropathy and renal failure and the molecular mechanisms regulating this process remain unknown, it is hypothesized that the elevated expression of MT5-MMP contributes to the activation of pro-MMP-2, which participates in the remodeling of the proximal and distal tubules as well as in the collecting duct.These provide the first evidence of the expression of a MT-MMP in diabetes and suggest a novel role for MT5-MMP in the pathogenesis of renal tubular atrophy and end-stage renal disease. | 11457723 |