| MT1A |
| LOCUS ID | 4489 | |||||||||||||
| GENE_SYMBOL | MT1A | |||||||||||||
| GENE NAME | metallothionein 1A | |||||||||||||
| SYNONYMNS | MT1, MTC, MT1S | |||||||||||||
| CHROMOSOME | 16 | |||||||||||||
| HOMOLOGENE ID | 0 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metall |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. this work provides novel evidence on the association of the +647 A/C MT1A polymorphism with DM2. Moreover, C+ carriers in DCVD patients presented a worse glycemic control, a reduced iZnR and a higher MT levels, suggesting a possible role of MT in diabetic cardiovascular complications. | 18249147 |
| Neuropathy | 1. Increased serum levels in diabetic patients were positively associated with rs964372 SNP, and type 2 diabetes with neuropathy was positively associated with rs10636 and rs11076161. These results suggest that multiple SNPs in MT genes are associated with diabetes and its clinical symptoms.MT1A gene in rs8052394 SNP is most likely the predisposition gene locus for diabetes or changes of serum superoxide dismutase activity. | 18349110 |