| MVP |
| LOCUS ID | 9961 | ||||||||||
| GENE_SYMBOL | MVP | ||||||||||
| GENE NAME | major vault protein | ||||||||||
| SYNONYMNS | LRP VAULT1 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 3752 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced tra |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Both global and myeloid-specific MVP gene knockout aggravates high-fat diet induced obesity, insulin resistance, hepatic steatosis and atherosclerosis in mice. | 30996248 |