MVP
LOCUS ID9961
GENE_SYMBOLMVP
GENE NAMEmajor vault protein
SYNONYMNSLRP VAULT1
CHROMOSOME16
HOMOLOGENE ID3752
microRNAsNANA
GENE SUMMARY
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced tra

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. Both global and myeloid-specific MVP gene knockout aggravates high-fat diet induced obesity, insulin resistance, hepatic steatosis and atherosclerosis in mice.30996248