| MyD88 |
| LOCUS ID | 4615 | ||||||||||||||||
| GENE_SYMBOL | MyD88 | ||||||||||||||||
| GENE NAME | myeloid differentiat | ||||||||||||||||
| SYNONYMNS | NA | ||||||||||||||||
| CHROMOSOME | 3 | ||||||||||||||||
| HOMOLOGENE ID | 1849 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogen |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. significant increased risk of T2DM for the AG genotype of rs6853 in MyD88 gene.In conclusion, our results indicate that the polymorphisms in TLR-MyD88-NF- kappa B signaling pathway confer genetic susceptibility to T2DM and DN. | 27062898 |
| Atherosclerosis | 1. Using network analysis, we have identified several cellular network proteins like PTPN1, AKT1, INSR, LEPR, IRS1, IRS2, IL1R2, IL6R, PCSK9 and MYD88, which are responsible for regulating inflammation, insulin resistance, and atherosclerosis. We have identified three distinct sets of serum markers for diabetes, CAD and diabetes associated with CAD in Indian patients using nonparametric-based machine learning approach. These multiple marker classifiers may be useful for monitoring progression from a healthy person to T2DM and T2DM to T2DM_CAD. | 30674322 |
| Insulin resistance and inflammation | 1. Inhibition or knockdown of the TLR4/MyD88 pathway attenuated inflammatory and hypertrophic responses to RBP4 stimulation. | 27100622 |