| NAGLU |
| LOCUS ID | 4669 | |||||||||||||
| GENE_SYMBOL | NAGLU | |||||||||||||
| GENE NAME | N-acetylglucosaminid | |||||||||||||
| SYNONYMNS | NAG, CMT2V, MPS3B, UFHSD, MPS-IIIB | |||||||||||||
| CHROMOSOME | 17 | |||||||||||||
| HOMOLOGENE ID | 222 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. The current study emphasizes a strong association of the tubular biomarkers NAG and KIM-1 with CKD progression in chronic heart failure and suggests their usefulness as cardiorenal markers. | 26422793 |
| Retinopathy | 1. The suggest that both serum NAG activity and albuminuria may serve as early functional indicators of diabetic retinopathy. | 1837508 |