| NAMPT |
| LOCUS ID | 10135 | |||||||||||||
| GENE_SYMBOL | NAMPT | |||||||||||||
| GENE NAME | nicotinamide phospho | |||||||||||||
| SYNONYMNS | VF, PBEF, PBEF1, VISFAT | |||||||||||||
| CHROMOSOME | 7 | |||||||||||||
| HOMOLOGENE ID | 4201 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Our data suggest that circulating NAMPT levels are associated with CAD in type 2 diabetic patients. NAMPT rs9770242 polymorphism may be associated with CAD in some populations | 23968400 |
| Insulin resistance and inflammation | 1. In subsequent analyses of leucocyte subpopulations, we identified higher NAMPT protein concentrations in lysates of granulocytes and monocytes compared with lymphocytes, whereas granulocytes secreted highest amounts of NAMPT protein into cell culture supernatant fractions. | 21298414 |