| NAPSA |
| LOCUS ID | 9476 | ||||||||||
| GENE_SYMBOL | NAPSA | ||||||||||
| GENE NAME | napsin A aspartic pe | ||||||||||
| SYNONYMNS | KAP Kdap NAP1 NAPA SNAPA | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 68418 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. KAP transgenic were protected from hfd-induced insulin resistance, increased blood pressure and exhibited lower IL-6 serum levels and diminished expression of inflammatory markers in the adipose. | 29170528 |