| NBR1 |
| LOCUS ID | 4077 | ||||||||||
| GENE_SYMBOL | NBR1 | ||||||||||
| GENE NAME | NBR1 autophagy cargo | ||||||||||
| SYNONYMNS | IAI3B M17S2 MIG19 1A1-3B | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 7438 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to t |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We also show that NBR1 inactivation in the myeloid compartment impairs the function, M1 polarization, and chemotactic activity of macrophages; prevents inflammation of adipose tissue; and improves glucose tolerance in obese mice. | 25043814 |