| NCF1 |
| LOCUS ID | 653361 | |||||||||||||
| GENE_SYMBOL | NCF1 | |||||||||||||
| GENE NAME | nuclear factor, eryt | |||||||||||||
| SYNONYMNS | p45, NF-E2 | |||||||||||||
| CHROMOSOME | 12 | |||||||||||||
| HOMOLOGENE ID | 4491 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil DPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The NF-E2-related factor 2-mediated protection against diabetic nephropathy is, at least partially, through inhibition of TGF-beta 1 and reduction of extracellular matrix production. Studies show activation or overexpression of NRF2 inhibits the promoter activity of TGF- beta 1, whereas knockdown of NRF2 by small interfering RNA enhances TGF-beta 1 transcription. | 24072144 |
| Tuberculosis | 1. The sequential evaluation of the mRNA levels of NCF1 and ORM as multiple diagnostic tests showed 95% Sensitivity (Se) and 80% Specificity (Sp). In addition, FPR2 promises to be a good biomarker for the PTB detection in subjects with NIDDM | 26628192 |