| NCF2 |
| LOCUS ID | 4688 | ||||||||||
| GENE_SYMBOL | NCF2 | ||||||||||
| GENE NAME | nuclear factor, eryt | ||||||||||
| SYNONYMNS | NRF2, HEBP1 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 2412 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein DPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other DPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Altertive splicing results in multiple transcript variants en |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Renal mRNA s and protein expressions of NF-E2 related factor 2 (Nrf2) were up-regulated by MG132 in comparison to DN alone. | 21241714 |