| NCOR1 |
| LOCUS ID | 9611 | ||||||||||
| GENE_SYMBOL | NCOR1 | ||||||||||
| GENE NAME | nuclear receptor cor | ||||||||||
| SYNONYMNS | N-CoR TRAC1 N-CoR1 hN-CoR PPP1R109 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 38166 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Despite increased obesity, glucose tolerance was improved in AKO mice (adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout (AKO) mice), and clamp studies demonstrated enhanced insulin sensitivity in liver, muscle, and fat. | 22078880 |