| NFE2L1 |
| LOCUS ID | 4779 | ||||||||||
| GENE_SYMBOL | NFE2L1 | ||||||||||
| GENE NAME | nuclear factor, eryt | ||||||||||
| SYNONYMNS | NRF1 TCF11 LCR-F1 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 20685 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Mechanistic studies revealed that Nfe2l1 deficiency may disturb the expression of lipolytic genes in adipocytes, leading to adipocyte hypertrophy followed by inflammation, pyroptosis, and insulin resistance. | 29935181 |