| NFKB1 |
| LOCUS ID | 4790 | |||||||||||||
| GENE_SYMBOL | NFKB1 | |||||||||||||
| GENE NAME | nuclear factor kappa | |||||||||||||
| SYNONYMNS | p50, KBF1, p105, EBP-1, CVID12, NF-kB1, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B | |||||||||||||
| CHROMOSOME | 4 | |||||||||||||
| HOMOLOGENE ID | 2971 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. NFKB1 promoter -94 ins/del AGGT SNP is associated with increased possibility of developing nephropathy in patients with diabetes. | 28265344 |
| Insulin resistance and inflammation | 1. Pertaining to ELS, relevant loci are FKBP5, EGR1, GSK3B; critical roles of inflammation are indicated by CRP, TNFA, NFKB1 modifications; for cholesterol biosynthesis, DHCR24; for myelin stability BIN1, SORL1, CNP; pertaining to (epi)genetic mechanisms, hTERT, MBD2, DNMT1, MTHFR2. | 30386171 |