| NLRC5 |
| LOCUS ID | 84166 | ||||||||||
| GENE_SYMBOL | NLRC5 | ||||||||||
| GENE NAME | NLR family CARD doma | ||||||||||
| SYNONYMNS | NOD4 NOD27 CLR16.1 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 88935 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. NLRC5 knockout mice fed with high fat showed accelerated fibrosis and inflammation response by promoting ?-SMA, Collagen I, Collagen III, TLR4/MyD88, phosphorylated IKK?, I?B? and NF-?B expression. | 28499247 |