| NOD1 |
| LOCUS ID | 10392 | ||||||||||
| GENE_SYMBOL | NOD1 | ||||||||||
| GENE NAME | nucleotide binding o | ||||||||||
| SYNONYMNS | CARD4 NLRC1 CLR7.1 | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 4440 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally locate |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. NOD1/2(-/-) mice were protected from HFD-induced inflammation, lipid accumulation, and peripheral insulin intolerance. | 21715553 |