| Complication | Evidence | PMID |
| Nephropathy | 1. Endothelial nitric oxide synthase (E-NOS) gene G894T polymorphism has been reported to be associated with endothelial dysfunction leading to DN. 2. Our data demonstrate that a modest decrease in eNOS, comparable to that associated with human NOS3 variants, is sufficient to enhance diabetic nephropathy independently of its effects on blood pressure (BP). | 25606424 |
| Cardiovascular | 1. Multiple changes in endothelial function and eNOS activity accompany the onset and development of Type 2 diabetes mellitus (T2DM) and contribute to the development of cardiovascular disease (CVD). 2- We show here a strong independent association between eNOS genotype and AMI in patients with T2DM. This suggests a synergistic effect of the eNOS Asp298 allele and diabetes, and confirms the role of eNOS as an important pathological bottleneck for cardiovascular disease in patients with T2DM. | 22044039 |
| Retinopathy | 1. Genetic polymorphisms of eNOS gene have been suggested to play a role in nitric oxide (NO) abnormalities which may contribute to the development and progression of DR. 2. We observed a significant association between the 4a/b polymorphism of the eNOS and DR in our West African cohort | 23085930 |
| Atherosclerosis | 1. Direct eNOS activation provides atheroprotection in diabetes-accelerated atherosclerosis. | 26116699 |
| Neuropathy | 1. The study indicates association of RAS variants with obesity and nephropathy, and an opposite effect of NOS3 VNTR and NOS3 G894T on the occurrence of combined microangiopathy. | 26116699 |
| Dyslipidemia | 1. The risk also holds for the G894T and T-786C eNOS gene polymorphisms when excluding patients with dyslipidemia and cardiovascular diseases (p?=?1.7?10-4 and p?=?3.2?10-5 , respectively). | 26116699 |
| Insulin resistance and inflammation | 1. The eNOS gene polymorphisms appear to be associated with SVI(sympathovagal imbalance) in young prehypertensives attributed by insulin resistance and inflammation.? | 21406182 |
