| NPPC |
| LOCUS ID | 4880 | ||||||||||
| GENE_SYMBOL | NPPC | ||||||||||
| GENE NAME | natriuretic peptide | ||||||||||
| SYNONYMNS | CNP CNP2 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 7867 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. The endogenous peptide C-type natriuretic peptide (CNP) binds its receptor, guanylyl cyclase B (GCB), and is expressed by endothelial cells in diverse tissues. | 28852070 |