GENE NAMEneuropeptide Y
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes including cortical excitability stress response food intake circadian rhythms and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase activate mitogen-activated protein kinase (MAPK) regulate intracellular calcium levels and activate potassium channels. A polymorphism in this gene resulting in a


Complication Evidence PMID
Nephropathy1. The present study has, for the first time, shown high plasma IR-NPY concentrations and Urinary IR-NPY excretion in NIDDM patients with advanced nephropathy.10426578
Retinopathy1. NPY and Y2-receptor play important roles in diabetic retinopathy and retinal neovascularization and are thus potential new targets for drug molecules for treatment of retinopathy.15181979
Atherosclerosis1. The indicate significant associations between inflammatory cell activation in blood and vascular atherosclerosis in genetically prone subjects, and provide possible mechanistic information about the role of NPY and the Leu7Pro polymorphism in the development of atherosclerosis.21746772
Neuropathy1. These demonstrate that the expression of neuropeptides and their receptors in the diabetic heart is significantly impaired, and may be the link between neuropathy and cardiac complications. Further studies are warranted to delineate pathophysiologic mechanisms associated with dysregulation of the cardiac neuropeptide system and the relationship to cardiac complications in diabetes.22029806
Cardiovascular1. In addition to incretin hormones, there are several proteins that may be affected by DPP-4 and its inhibition: among these some are relevant for the cardiovascular system homeostasis such as SDF-1\316\261 and its receptor CXCR4, brain natriuretic peptides, neuropeptide Y and peptide YY.22029806
Dyslipidemia1. High or low abundance of NPY and cognate receptors dysregulates the homeostatic milieu engendering hyperphagia, decreased energy expenditure, obesity and attendant metabolic syndrome cluster of dyslipidemia, glucose intolerance, insulin resistance and hyperinsulinemia, risk factors for type II diabetes and cardiovascular diseases.22029806
Insulin resistance and inflammation1. Increased FOXO1 positively correlated with NPY mRNA levels in D IRS2(-/-) mice, with FOXO1 showing mainly nuclear localization in D IRS2(-/-) and cytoplasmic in ND IRS2(-/-) mice. 29667232