| NR3C1 |
| LOCUS ID | 2908 | ||||||||||
| GENE_SYMBOL | NR3C1 | ||||||||||
| GENE NAME | nuclear receptor sub | ||||||||||
| SYNONYMNS | GR GCR GRL GCCR GCRST | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 30960 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Consequently, aberrant glucocorticoid signaling is linked to severe metabolic disorders, including insulin resistance, obesity, and hyperglycemia, all of which also appear upon chronic glucocorticoid therapy for the treatment of inflammatory conditions. | 30742779 |